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Complex development of biological products for medicine, veterinary and cosmetology

  • Complex development of biological products for medicine, veterinary and cosmetology

    The company "Pharma gene" provides services and performs research and development in the following areas:

    1. Patent Research

    2. Gene and protein engineering to create a biopharmaceutical drugs.

    3. The development of non-viral delivery methods of gene therapy constructs.

    4. Development of protein preparations for medicine, veterinary medicine and cosmetology.

    5. Development of stable liquid dosage forms of the recombinant proteins.
    • Development dosage form supporting recombinant proteins for a long time in dissolved form
    • Analysis of the refolding and storage efficiency by the original method

    6. Create drugs based on humanized chimeric monoclonal antibodies.
    • sequencing of the genes encoding the variable domains of a mouse MAb
    • Creating bicistronic vectors containing genes encoding the variable domains of the mouse MAb and the constant domains of human IgG1
    • Preparation of stable CHO cell lines
    • Annotate the variable domains of mouse MAbs using a modified algorithm Kabat - Chothia and molecular modeling conformational homology of the antibody with taking into account the CDR and FR structure, as well as data on VH / VL folding corners in the donor and acceptor antibodies
    • transfer of the CDR from donor mouse monoclonal antibody to the chosen human acceptor antibody
    • Increasing the affinity of humanized antibodies using a combinatorial directed mutagenesis of the predicted amino acid residues that affect the antibody affinity

    7. Development of medical and veterinary preparations for gene therapy
    • Create a vector for gene therapy based on plasmid DNA
    • Development of technology for scalable ion-exchange chromatographic purification of plasmid DNA.

Scientists grow cartilage to reconstruct nose
Scientists report first ever successful nose reconstruction surgery using cartilage grown in the laboratory. Cartilage cells were extracted from the patient's nasal septum, multiplied and expanded onto a collagen membrane. The so-called engineered cartilage was then shaped according to the defect and implanted (URL:
Botox doctor to Hollywood stars takes his own life Apr 7, 2015
Pioneering dermatologist Dr Fredric Brandt, an early proponent of Botox who treated celebrities including singer Madonna, has been found dead. Police found his body at his home in the Coconut Grove area of Miami, Florida, on Sunday, after being contacted by a friend.(URL: